Read e-book online Amorphous Solid Dispersions: Theory and Practice (Advances PDF

By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick

ISBN-10: 1493915975

ISBN-13: 9781493915972

ISBN-10: 1493948660

ISBN-13: 9781493948666

This quantity deals a entire consultant at the idea and perform of amorphous strong dispersions (ASD) for dealing with demanding situations linked to poorly soluble medications. In twenty-three inclusive chapters, the e-book examines thermodynamics and kinetics of the amorphous nation and amorphous reliable dispersions, ASD applied sciences, excipients for stabilizing amorphous strong dispersions equivalent to polymers, and ASD production applied sciences, together with spray drying, sizzling soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation expertise (MBP). every one expertise is illustrated via particular case reports. moreover, devoted sections conceal analytical instruments and applied sciences for characterization of amorphous reliable dispersions, the prediction of long term balance, and the improvement of appropriate dissolution tools and regulatory features. The publication additionally highlights destiny applied sciences at the horizon, reminiscent of supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.

Amorphous stable Dispersions: concept and perform is a necessary connection with pharmaceutical scientists attracted to constructing bioavailable and therapeutically powerful formulations of poorly soluble molecules as a way to enhance those applied sciences and boost larger drugs for the future.

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Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology) by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick

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